Statistical Modelling 11 (2011), 2547
Bayesian latent variable models for spatially correlated tooth-level
binary data in caries research
Y Zhang
Department of Epidemiology,
Michigan State University
USA
D Todem
Division of Biostatistics,
Department of Epidemiology,
Michigan State University,
East Lansing, MI 48823
USA
eMail: dtodem@epi.msu.edu
K Kim
Department of Biostatistics & Medical Informatics,
University of Wisconsin-Madison
USA
E Lesaffre
Department of Biostatistics,
Erasmus Medical Centre,
Erasmus University Rotterdam
The Netherlands
and
L-Biostat,
Catholic University of Leuven
Belgium
Abstract:
Analysis of dental caries is traditionally based on aggregated scores, which
are summaries of caries experience for each individual. A well-known example
of such scores is the decayed, missing and filled teeth or tooth surfaces
index introduced in the 1930s. Although these scores have improved our u
nderstanding of the pattern of dental caries, there are still some fundamental
questions that remain unanswered. As an example, it is well believed among
dentists that there are spatial symmetries in the mouth with respect to caries,
but this has never been evaluated in a statistical sense. An answer to this
question requires the analysis to be performed at subunits within the mouth,
which necessitates the use of methods for correlated data. We propose a
Bayesian generalized latent variable model coupled with an undirected graphical
model to investigate the unique spatial distribution of tooth-level caries
outcomes in the mouth. Data from the Signal Tandmobiel® study in Flanders, a
dental longitudinal survey, are used to illustrate the methodology.
Keywords:
hierarchical structure; latent variable;
multivariate conditional autoregressive models;
spatial correlation; undirected graphical Gaussian model
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